Autism Disorder is a neuro-developmental disorder usually noticed among children within the first two or three years of their lives which have a profound impairment in social communication and social interaction and restricted and repetitive behavior. Aim: To evaluate the effect of an educational program on enhancing knowledge, attitude and practices of parents having children with autism Design: A quasi-experimental research design was used. Setting: the study was carried out in the outpatient clinic of autismat Al-Abbassia hospital for mental health and addiction and Helwan hospital for psychiatric and mental health. Subjects: the study sample was 60 parents of children of children diagnosed with autism from both sex. Tools: data was collected by using four tools; Tool (1) socio-demographic questionnaire for the characteristic of the children and their parents, Tool (2) parent's knowledge scale regarding autism disorder. Tool (3) Attitude scale of parents toward their children with autism, Tool (4) parent's practices scale regarding caring of children with autism. Results: the study results showed that. There was a highly statistically significant positive correlation between total knowledge and total practices scores and negative correlation between total knowledge, total practices scores and total attitude score. Conclusion: The educational program has positive effect on enhancing the parents of children with autism knowledge, attitude and practices. Recommendation: Conducting a continuous practical training and health educational programs for all members of the families having children with autism focuses on the attitude and behavior modification techniques.