Background: Mechanical ventilation is a therapeutic modality which is commonly used to support the respiratory function of patients with life-threatening illnesses. Mechanical ventilation is not an intervention without complications. The ventilator management should be aimed at getting the patient off ventilator support as rapidly as possible. Repeated ventilator weaning failure can cause prolonged mechanical ventilation period. Aim of the study:To determine the effect of co-ordinated spontaneous awakening and breathing trials protocol on the duration of ventilation among mechanically ventilated patients.