paracentesis is a common invasive method for managing patients with ascites; but it is associated with many potential complications. Nurses play a crucial role in preventing of complications by providing special care before, during and after the procedures. Aim: The study aimed to evaluate the effect of designated nursing guidelines for nurses on the incidence of cirrhotic complications among paracentesis patients. Research design: A quasi experimental research design was utilized in this study. Setting: This study was conducted in the internal medicine and Endemic diseases departments in Fayoum University Hospital. Sample: Convenient sample of all available nurses about (30) working at the internal medicine and Endemic diseases departments and purposive sample of 60 adult patients who are divided randomly into two equal groups pre and post implementation of nursing guidelines. Tools: Three tools were used for data collection An interview questionnaire to assess level of nurses ’knowledge , observational checklist to assess level of nurses ’practice and Patient complications assessment questionnaire. Results: The study results revealed that there was a highly significance improvement in total level of nurses' knowledge and practice regarding care of paracentesis patient after implementation of nursing guidelines than before in addition to incidence of paracentesis complications among paracentesis patient were less than before. Conclusion: The application of nursing guidelines about paracentesis care enriched nurses' knowledge, practice and decrease the incidence of complications among paracentesis patient. Recommendation: Continuous nursing education about paracentesis care is recommended to upgrade the knowledge and skills of nurses.