Effective and adequate post-operative analgesia for cesarean section is in demand as it may help promote recovery and early ambulation. Local nerve block has been applied as post-operative analgesia for patients undergoing cesarean section specifically, lateral abdominal Transversus Abdominis plane block (TAP) under ultrasound guidance have been proven to be effective. The present study aimed to compare the analgesic effect of addition dexmedetomidine intrathecally to the effect of dexmedetomidine in Tap block in CS compared to bupivacaine alone. 150 patients were recruited to undergo cesarean section and divided into three groups; The first group spinal anesthesia was performed with hydrochloride bupivacaine 10-12 mg and TAP block was performed with 30 ml 0.25% bupivacaine in each side and the second group Spinal anesthesia was performed with hydrochloride bupivacaine 10-12 mg and TAP block was performed with 50 mcg Dexmedetomidine added to 30ml 0.25% bupivacaine in each side and the third group Spinal anesthesia was performed with hydrochloride bupivacaine 10-12 mg added to 5 mcg dexmedetomidine and TAP block was performed with 30ml 0.25% bupivacaine in each side. Demographic and clinical data were collected and compared, including time of first request of analgesia in hours, Intraoperative hemodynamics, VAS score during first 24 hours postoperatively, Nausea and vomiting in both intraoperative and postoperative periods, Motor power in both intraoperative and post-operative periods, Sensory level in both intraoperative and post-operative periods, Complications of spinal anesthesia and TAP block during 12 hours post-operative period. Our study showed that the addition of dexmedetomidine to bupivacaine in TAP block has been proved to prolong the duration of time at which first dose of rescue analgesia was sought and also the total dose of opioid requirement in the first 24-h post-Caesarean section was reduced than addition of dexmedetomidine intrathecally and use of bupivacaine alone