Background: Chronic kidney disease (CKD) is an important worldwide health problem. Multidrug interventions with the least adverse effects should be investigated in attempts to stop CKD progression. This study aims to evaluate the effect of pentoxifylline (PTF) on CKD progression regarding serum creatinine, estimated glomerular filtration rate (eGFR), urinary Albumin/creatinine (A/C) ratio and blood hemoglobin level. This study included 53 patients with CKD stages 3-4, stable clinical condition and stable renal function were randomly assigned to continue with their standard treatment (control group: 23 patients) or to treatment with oral pentoxifylline (pentoxifylline group: 30 patients), at 400 mg twice a day to be reduced to 400 mg once daily in patients with severe renal dysfunction (Creatinine clearance < 50ml/min) for six months. Serum creatinine, eGFR (by the Modification of Diet in Renal Disease (MDRD) study equation) and urinary protein excretion will be monthly monitored for 6 months and picked-up at the end of the study