Background: Globally, an estimated 46.8 million people have Alzheimer's diseases and dementia and this figure is expected to almost treble by 2050. Deaths due to Alzheimer’s disease and other dementias more than doubled between 2000 and 2015 making it the seventh leading cause of death worldwide. Most people, particularly in the early stages of Alzheimer's diseases and dementia, live at home and are cared for by family members or friend's hereafter referred to as ‘carers’ estimated to provide the equivalent of more than 40 million full time workers worldwide. The Saudi Arabia Association of Palliative Care recommends that family carers need education about the knowledge of Alzheimer's diseases and the progression of dementia. Dementia is characterized by progressive cognitive decline, memory impairment, and disability. Alzheimer's diseases dementia accounts for 60–70% of cases followed by vascular and mixed dementia. Saudi Arabia and the Middle East are at increased risk owing to aging populations and high prevalence of vascular risk factors. Appropriate levels of knowledge and awareness amongst health care professionals (HCPs) are the need of the hour. Aim of the study: To explore the effected of health education about Knowledge of Alzheimer's diseases and dementia in family caregivers in Saudi Arabia 2022. Methods: A cross-sectional study was conducted at200 family caregivers of patients diagnosed as Alzheimer's diseases and dementia in a third-class hospital in in Saudi Arabia, from April to May 2022, were selected for this study of convenient sampling. These patients were followed up at home after discharge from the hospital, and their main family caregivers were investigated by knowledge questionnaire. Results: shows that most of the participants (79.0%) were in the age group (>50) years, regarding self-care ability the majority of participant needing help occasionally were(33.0%), regarding state of occupation work the majority of participant are freelancer were(46.0%), regarding the marital status most of participants not married were(69.0%). Conclusion: There was not sufficient evidence to support nor refute the effectiveness of health education on progression of about Knowledge of Alzheimer's diseases and dementia on family caregivers, further robust research is required that use educational interventions regarding the progression of Alzheimer's diseases and dementia family caregivers.