This study examines the effectiveness of different nurse-patient communication strategies on patient satisfaction and health outcomes. A randomized controlled trial was conducted with 100 patients who were hospitalized for at least 24 hours. Patients were randomly assigned to receive either active listening, empathy, or cultural sensitivity communication strategies from their nurses, in addition to standard care. Patient satisfaction and health outcomes were measured using a patient satisfaction survey and clinical indicators, respectively. The results show that patients who received active listening and empathy communication strategies reported higher levels of satisfaction with their care and experienced better physical and emotional well-being compared to those who received standard care. In contrast, patients who received cultural sensitivity communication strategies reported lower levels of satisfaction with their care. The findings of this study suggest that the use of active listening and empathy communication strategies by nurses can be an effective way to improve patient satisfaction and health outcomes. These strategies can help build trust and rapport between nurses and patients, promote patient-centered care, and improve patient outcomes.