Background: Diabetes mellitus (DM) is a prevalent chronic metabolic disorder affecting millions globally. The rise in DM cases poses a significant public health challenge, with associated complications leading to increased healthcare resource utilization. Nurses play a crucial role in DM management, including patient education, self-management support, interprofessional teamwork, prescribing medications, telephone interventions, and psychological care. Objective: This research article aims to underscore the vital contributions of nurses in the comprehensive management of diabetes mellitus. By examining the various roles and interventions carried out by nurses in diabetes care, the study seeks to highlight the impact of nurse-led initiatives on patient outcomes, self-care practices, and overall health management for individuals with diabetes. Conclusion: Nurses are pivotal in the holistic care of individuals with diabetes, offering a range of services from education to psychological support. Nurse-led interventions have been shown to improve patient outcomes, enhance self-care knowledge, and promote better health management in diabetes. By empowering patients, bridging communication gaps, and providing tailored support, nurses play a critical role in enhancing the quality of life and clinical outcomes for those living with diabetes. The findings underscore the indispensable contribution of nurses in the multidimensional care of individuals with diabetes, emphasizing the significance of nurse-led interventions in optimizing diabetes management and patient well-being.