Smoking cessation programs led by nurses have gained recognition as effective interventions in promoting smoking cessation and improving public health outcomes. This review article aims to critically evaluate the effectiveness of nurse-led smoking cessation programs in helping individuals quit smoking. The review synthesizes current literature on the subject, highlighting key findings, methodologies, and outcomes of nurse-led interventions. Various aspects of nurse-led smoking cessation programs, including counseling techniques, behavioral interventions, pharmacotherapy, and follow-up support, are discussed in detail. The review also examines the role of nurses in addressing smoking cessation within the broader healthcare system and the impact of these programs on patient outcomes and healthcare costs. Furthermore, the review explores the challenges and opportunities associated with nurse-led smoking cessation initiatives, such as training and education requirements, patient engagement, and program sustainability. By providing a comprehensive overview of the effectiveness of nurse-led smoking cessation programs, this review aims to inform healthcare professionals, policymakers, and researchers about the potential benefits and limitations of these interventions in promoting smoking cessation and reducing the burden of tobacco-related diseases.