Obesity has become a significant public health concern globally, with adverse effects on individuals' health and well-being. Nurse-led weight management programs have emerged as a promising approach to address this issue. This study aims to evaluate the effectiveness of nurse-led weight management programs in reducing obesity rates. A systematic review of relevant literature was conducted, focusing on studies that implemented nurse-led interventions for weight management. The findings suggest that nurse-led programs can lead to significant reductions in obesity rates among participants. Nurses, with their unique blend of clinical expertise and patient-centered care, play a crucial role in empowering individuals to make sustainable lifestyle changes that promote weight loss and improve overall health. The study highlights the importance of multidisciplinary collaboration, personalized care plans, and ongoing support in achieving successful weight management outcomes. Further research is warranted to explore the long-term impact and scalability of nurse-led interventions in combating obesity on a larger scale.