This study aimed to assess the effectiveness of nurse-led wound care programs in reducing infection rates among patients with acute and chronic wounds. A systematic review of relevant literature was conducted, and data from various studies were analyzed to evaluate the impact of nurse-led wound care interventions on infection rates. The results showed that nurse-led wound care programs were associated with a significant reduction in infection rates compared to standard care. These programs were found to improve wound healing outcomes, reduce hospital readmissions, and enhance patient satisfaction. Overall, the findings suggest that nurse-led wound care programs are effective in reducing infection rates and improving clinical outcomes for patients with acute and chronic wounds.