Objectives:The study's objective is to examine the effectiveness and safety of intravenous oxytocin and intravenous tranexamic acid (TXA) in minimising intraoperative bleeding during open myomectomy. Method:A total of 75 patients who met the inclusion criteria and had uterine fibroid were scheduled for abdominal myomectomy. In a 1:1:1 allocation ratio, patients were randomly assigned to one of three groups. The groups were divided into three categories: Tranexamic acid (group A), oxytocin (group B), and control (group C) (n=25 per group). Estimated blood loss (EBL) during open myomectomy, need for intraoperative and postoperative blood transfusion, operating time, myomectomy time, postoperative hematocrit and hemoglobin, drop in postoperative hematocrit, side effects of TXA and oxytocin, as well as postoperative stay in days, were all achieved in each of the three groups.