Background: Orthopedic foot and ankle conditions are prevalent and can significantly impact an individual's quality of life. Non-surgical interventions represent a critical aspect of their management. This comprehensive review and meta-analysis aim to assess the efficacy of various non-surgical treatments in alleviating the symptoms and improving the outcomes of orthopedic foot and ankle conditions. Aim: The primary objective of this study is to systematically evaluate the effectiveness of non-surgical interventions, including physical therapy, orthotics, bracing, exercise regimens, and other conservative approaches, in the management of orthopedic foot and ankle conditions. We seek to provide evidence-based insights that can guide both patients and healthcare providers in making informed treatment decisions. Methods: We conducted an exhaustive literature search across multiple databases, retrieving relevant studies published from inception to the present day. Eligible studies were selected based on predetermined inclusion and exclusion criteria. Data extraction and quality assessment were performed systematically. A meta-analysis was carried out to synthesize the findings, and heterogeneity was evaluated. Subgroup analyses were conducted to explore potential sources of variation. Results: The meta-analysis of non-surgical interventions for orthopedic foot and ankle conditions revealed promising outcomes. Our findings indicate that these treatments can significantly reduce pain, improve functional outcomes, and enhance patients' overall well-being. Subgroup analyses shed light on the relative effectiveness of different intervention types and their suitability for specific conditions. Conclusion: Non-surgical interventions are valuable and effective options in the management of orthopedic foot and ankle conditions. Patients and healthcare providers should consider these treatments as primary or adjunctive strategies in their care plans. The comprehensive review and meta-analysis presented in this study offer a valuable resource for evidence-based decision-making and underscore the importance of non-surgical approaches in the field of orthopedics.