The objectives of this research were: 1) to study the care and prevention of people at risk of COVID-19 infection; 2) to study the guidelines for the Buddhist care and prevention of people at risk of being infected with COVID-19 Mueang Phia Sub-district Shelter, Ban Phai District, Khon Kaen Province; 3) to propose the guidelines for the Buddhist care and prevention of people at risk of being infected with COVID-19 Mueang Phia Sub-district Shelter, Ban Phai District, Khon Kaen Province. This study was carried out by means of qualitative research through in-depth interviews with 25 key informants. The obtained data were interpreted by descriptive analysis. The research results were as follows: The care and prevention of people at risk of COVID19 infection: it is to take care of physical health through behavior modification. Mental health care should be appropriate to the situation. Risk groups were important, therefore, there were staff waiting to provide service. There was a disinfectant sprayer, a sink, and a thermometer with alcohol service points. There were screenings for participants in the event and ATK inspection service point, a group of volunteers came to spray disinfectants in the risky areas, and garbage was collected. The guidelines for the Buddhist care and prevention of people at risk of being infected with COVID-19 Mueang Phia Sub-district Shelter, Ban Phai District, Khon Kaen Province: in terms of conduct: there is a change in behavior in being. In terms of mental development: one should train the mind by chanting to make it mind strong and stable. In terms of meditation: one should accept what is about to happen, and be aware of the situation to relax the mind. In terms of physical and mental care: one should have adjustments to take care of oneself and society. The proposed guidelines for the Buddhist care and prevention of people at risk of being infected with COVID-19 Mueang Phia Sub-district Shelter, Ban Phai District, Khon Kaen Province: physical aspect: giving alms and keeping the precepts is another way to calm the mind in situations arising from changing circumstances. Mental aspect: one should take care of mental health to suit the situation of the risk group by listening to the Dharma, and meditating to relax the situation. In the aspect of living: one should apply the five precepts to life or adapt to life. In the aspect of the environment in society: organization of environment by wearing a mask disinfectant spraying, having a sink, a thermometer with alcohol service points. There were ATK inspection service points, a group of volunteers who came to spray disinfectants in the risky areas, and garbage was collected.