Effective nurse-patient communication is paramount in healthcare, impacting various patient outcomes and care quality. This narrative review explores communication models, techniques, factors influencing communication, challenges, strategies for improvement, ethical considerations, and future directions. Communication skills training, interdisciplinary collaboration, technology integration, and culturally competent care emerge as key strategies for enhancing communication efficacy. Ethical considerations such as privacy, informed consent, and shared decision-making underscore the importance of patient-centered communication. Research gaps, policy implications, and practical recommendations are discussed to advance communication excellence in healthcare. The manuscript concludes by highlighting the critical role of nurse-patient communication in shaping patient experiences, treatment adherence, and healthcare outcomes, emphasizing the need for ongoing commitment to communication excellence in nursing practice.