Shift work is a common practice in the nursing profession, allowing healthcare facilities to provide round-the-clock care to patients. While essential for maintaining continuous healthcare services, shift work can have a significant impact on the health and well-being of nurses. This review article examines the various ways in which shift work influences nurse health and well-being, considering both physical and mental aspects. The review synthesizes existing literature on the topic, highlighting the challenges faced by nurses working non-traditional hours and the potential consequences for their overall health. Factors such as disrupted sleep patterns, increased stress levels, and difficulties in maintaining a healthy work-life balance are discussed in relation to shift work and its effects on nurse well-being. Additionally, strategies and interventions aimed at mitigating the negative impact of shift work on nurse health are explored, emphasizing the importance of organizational support and individual coping mechanisms. By shedding light on the complex relationship between shift work and nurse health, this review aims to raise awareness of the challenges faced by healthcare professionals and promote the development of policies and practices that prioritize the well-being of nurses in shift-based roles.