Catheter-related infections (CRIs) and dysfunction are the chief complications of Catheters causing morbidity and mortality in patients on hemodialysis. Methods: prospective, randomized controlled trial (RCT); two lock regimens using two commercial catheter lock solutions were compared in hemodialysis patients with newly inserted tunneled central catheters. There were two groups of patients. The first received 0.5 mL of Taurolock solution (Taurolidine group), and the other group received 0.5 mL of unfractionated heparin (Heparin group) before the catheter lock. Both groups were compared regarding catheter-related infections (CRI), catheter dysfunction, and hospital admission. Results: Over one year of catheter insertion, two catheter-related infections occurred in 40 patients in the Taurolidine group (TG), and ten CRIs occurred in 46 patients in the heparin group (HG) (p =0.031*). Catheter dysfunction rates were significantly lower in the TG (p=0.004*), and hospitalization for CRI events was significantly lower in the TG (p-=0.032*). Conclusion: The use of taurolidine-based catheter lock solutions significantly reduces CRIs, dysfunction, and overall hospitalization rates related to tunneled hemodialysis catheters compared to heparin solution.