The present study aimed to assess the antidiabetic and antioxidant potential of green synthesized Silver nanoparticles from different extracts of Chrysanthemum indicum. The Ethanolic, Petroleum ether, and Hydro-alcoholic flower extracts were used to synthesize Silver nanoparticles. The DPPH free radical scavenging assay was performed in Silver nanoparticles synthesized from three plant extracts, among the nanoparticles synthesized, the AgNPs synthesized from hydro-alcoholic extract shows the highest scavenging of DPPH radical comparable to the standard ascorbic acid. The IC50 value of AgNPs synthesized from hydro-alcoholic extract was 62.03 µg/ml and the standard Ascorbic acid was 52.0 µg/ml. The in-vitro antidiabetic activity of AgNPs synthesized from Ethanolic, Petroleum Ether, and Hydro-alcoholic flower extracts was studied. The AgNPs synthesized from hydroalcoholic flower extract shows good antidiabetic activity comparable to other extracts. The Alpha Glucosidase inhibitory assay revealed the IC50 value of AgNps synthesized from Ethanolic extract was 72.35 µg/ml, Petroleum Ether was 79.23 µg/ml and Hydro alcoholic was 60.05 µg/ml and compared with standard Acarbose 50.25 µg/ml. The AgNPs synthesized from Hydro alcoholic flower extract shows good antidiabetic activity. In the Alpha -amylase inhibitory assay, the IC50 value of AgNps synthesized from Ehanolic extract was 80.32 µg/ml, Petroleum Ether extract was 93.05 µg/ml and Hydroalcoholic extract was 65.23 µg/ml and the standard Acarbose was 50.25 µg/ml. The AgNps synthesized from Hydroalcoholic flower extract expressed its best result 47.16±0.96 at the 1mg/ml concentration. The AgNps synthesized from Hydroalcoholic flower extract showed higher inhibitory potential against diabetes.