Inflammasomes are the sensors/receptors of the innate immune system and are responsible for the activation of caspase-1. It enhances the rate of inflammation in response to molecules originating from host proteins and infectious microbes. It has been involved in a host of inflammatory disorders. Inflammasomes are first-line immune pathways and regulate two defense responses to defense host cells: the proinflammatory cytokines synthesis and pyroptosis induction or programmed cell death. Assembly of the inflammasome complex requires a range of biochemical signals that come out during infections, metabolic variations, or tissue damage.