The Education Area of Kentingan in Surakarta City has a function as a new growth center. The area has implicated the development of commercial activities in the surrounding area, especially in the area of Kartika Street. The purpose of this study is to find out commercial activities effects from how to transform settlement space utilization in the area Kartika Street. Quantitative method will be applied with spatial analysis and quantitative descriptive technique that uses primary and secondary data. The subject of this research is commercial in the area of Kartika Street. The results of the analysis showed a comprehensive phenomenon of space utilization of settlement spaces into commercial in the education area and finding 4 factors formed that affect in space utilization, namely higher education factors, location factors, accessibility factors, as well as economic factors