The purpose of this work is to find out the effect of using PBL and Macromedia Flash models on the operation and results of the chemistry teaching material. The population of this study was students of Class X IPA SMA Negeri 2 Tebing Tinggi, a total of 7 classes and 2 classes were purposely taken as experimental class and control class. As an instrument, a test instrument in the form of a test of learning outcomes of chemical bonding material and a non-test instrument in the form of activity observation sheets are used. The data obtained are normally distributed and homogeneous. The effect of the use of media, Macromedia Flash and Powerpoint, on the learning results and activities of both classes was determined by a one-tailed t-test, and a two-tailed t-test was used to determine student differences. n profit at a significant 5% level. From the results of data processing, learning scores were tcount = .393 and activity tcount = .619, while ttable = 1.667, while the t-power test gave tcount = 3. 782 and ttable = 1.995. Tcount>table observation shows the acceptance of the alternative hypothesis, therefore it can be concluded that the use of PBL and Macromedia Flash models has an impact on the chemical learning activities and results of students, where the average, activity and n-confirmation of learning results in the experimental class are better than in the control class. This study also concluded that the use of PBL models and Macromedia flash in chemical bonding material is a very good addition to student learning outcomes and online course activities.