Mental health is essential elements of old age people followed by Physical Health. In India, Families in India are united up with invisible connection, cooperation, togetherness and respect towards elders. The urbanization and modernization have led to drifting changes in Intergenerational relationships among younger generation and older generation. This change has huge impact on mental health of old age. The current study examined on the effect of Perceived respect on Loneliness and Mental Health among Senior Citizen. The research was conducted with 60 senior citizen randomly selected in the area of Salem city. The study used the Perceived Respect from Younger Generation scale, Positive mental health inventory, De Jong GierVeld Loneliness Scale. As Hypothesized, the results revealed that Perceived respect from younger generation is mediating the relationship between loneliness and mental health of Senior citizen. Consequently, to improve Mental Health of the Senior Citizen, positive Intergenerational interaction should be focused.