In-silico docking analysis has emerged as a powerful tool for predicting the multi-targeted therapeutic effects of bioactive compounds. In this study, we aimed to investigate the potential multi-targeted therapeutic effect of Solasodine, a natural compound, in menopausal syndrome. Specifically, we focused on its interaction with four key targets involved in menopausal syndrome: TNF Alpha, Caspase-3 (CASP-3), Catalase (CAT), and Estrogen Receptor (ER). Using molecular docking simulations, we evaluated the binding affinity and interactions of Solasodine with these target proteins. The results revealed favorable binding energies and strong interactions between Solasodine and the target proteins, suggesting a potential therapeutic effect of Solasodine on menopausal syndrome through multi-targeted modulation. Docking analysis of Solasodine with TNF Alpha, a pro-inflammatory cytokine implicated in menopausal symptoms, demonstrated a high binding affinity, indicating its potential as an anti-inflammatory agent. Furthermore, Solasodine exhibited strong interactions with CASP-3, a key protein involved in apoptosis, suggesting its potential role in regulating cell death pathways associated with menopausal syndrome.