The number of students with disabilities continues to increase in university so, it is critical that the faculty staff members have knowledge, positive attitude and able to adapt to make appropriate accommodations for student with disability. Aim: the study aimed to assess the perception and accommodation of faculty staff member for student with disability at Helwan university campus. Design: Descriptive research design was applied in this study. Sample: A convenient sample used was 364 faculty staff members`. Setting: Study conducted at Helwan University campus, Faculty of Pharmacy, Law, Commerce, Social Services, Engineering, Science, Tourism and Hotel, Computer and Information and Arts Education. Tools of data collection: one tool was used for data collection include an interview questionnaire that consisted of four parts: Part I: Demographic characteristic of faculty staff members`, Part II: Faculty staff members` knowledge, part III: Faculty staff members` attitude, part VI: Faculty staff members` accommodation regarding student with disability. Result: The study results revealed that, 87,30% of studied faculty staff members` had good knowledge, 91.50% of studied of faculty staff members` had positive attitude and 91.50% of studied of faculty staff members` had positive accommodation regarding student with disability. Conclusion: There was a highly significant positive correlation between total knowledge scores, total attitude scores and total accommodation score regarding students with disability. Recommendations: Continuous health education program for faculty staff members` regarding student with disability.