Phthalates have been linked to numerous adverse health effects, yet, the relationship between phthalate exposure and coronary heart disease (CHD) remains unclear. This study aims to investigate the possible association between phthalate exposure, indicated by urinary concentrations of Mono-2-ethylhexyl phthalate, and CHD. Subjects & Methods: This case-control study included 110 participants divided into two groups; Group (A) comprised 55 patients with CHD, and Group (B) comprised 55 healthy participants. Urinary concentrations of MEHP were measured using high-performance liquid chromatography. Results: There was a highly significant difference between groups (A and B) regarding the urinary level of MEHP (p-value < 0.001). Also, significant relationships were observed between MEHP urinary level and the number of coronaries affected (p-value= 0.001) and the coronary lesion type (p-value <0.001). Conclusions: This study indicated that urinary MEHP levels are associated with CHD. Exposure to phthalates could be linked to the development of hypertension and atherosclerosis as leading causes of CHD.