Obesity is complicated to treat and is a significant risk factor for some health problems such as diabetes and cardiovascular disease. Since drug treatment of obesity induces many side effects and has little long-term efficacy, natural plant extracts have been suggested to use as an alternative for long-term weight control. Cyanidin 3-glycoside is the predominant anthocyanin in blackberries found to prevent obesity in mice fed a high-fat diet correlated to mice fed a high-fat diet without anthocyanins. Obesity tends to result in increased risks of insulin resistance. Emerging evidences have proved the potential role of dietary consumption of foods containing phenolic constituents in attenuating insulin resistance induced by obesity. In an interventional study, 22.5 g blueberry powders containing 731 mg total phenolics and 334 mg anthocyanins were supplied for the participants diagnosed as obesity and insulin resistance twice daily for six weeks, which significantly improved insulin sensitivity compared to those without consumption of blueberry bioactives. Consumption of strawberry beverage rich in pelargonidin 3-glucoside and pelargonidin 3-malonylglucoside could attenuate the postprandial inflammatory response by lowering the level of high-sensitivity C-reactive protein and interleukin-6 (IL-6). Moreover, a recent human study has demonstrated that incorporating polyphenol from bilberries and lingonberries into breakfast could improve blood lipid profile efficiently with TC, TG and LDL-c decreased in overweight individuals