The link between iron deficiency anemia (IDA) and lymphocytopenia is not well established in the literature. This study aims at assessing the prevalence and clinical impact of lymphocytopenia in IDA patients considering the impact of iron replacement on the total and differential WBCs count. Subjects and Methods: The records of all female patients with IDA who attended our Hematology Central Laboratory (April 2022 to April 2023) were retroprospectively reviewed. Age, CBC, and iron parameters were collected before and after treatment. (IV iron therapy and oral iron). Results: Out of 103 adult females with IDA, 48 patients had lymphocytopenia (46.6%). After iron therapy, their mean lymphocytes increased significantly towards normal range. However, no significant correlation was found between leukocytes, Neutrophil count with Serum ferritin. Conclusions: Lymphocytopenia may occur in patients with IDA and are reversible with iron therapy. Iron therapy led to the correction of anemia in 100% and increased lymphocytes count in all 46.6% patients.Therefore, lymphopenic women with IDA should be treated, initially only with iron, and observed for their Hb and lymphocyte count responses before starting any other treatment.