Background: Mechanically ventilated patients are a risk group whose outcomes are negatively affected by many factors. Among these factors is sedation because it is a cornerstone therapy for critically ill patients Aim: This study aimed to assess the relationship between daily sedation interruption and selected patient outcomes among mechanically ventilated patients Design: a descriptive correlational research design was utilized to carry out this study Setting: The study was conducted at ICUs of Shebin El Qanater Central Hospital Sample: A purposive sample of (68) patients from both gender was included in the study. Tools: data were collected through using four tools, Tool (I) patient's structured interview questionnaire that included two parts, part I patient's demographic characteristics of the studied patients and part II: patients medical data. Tool (II) Richmond agitation section scale (RASS) Tool (III): Behavioral pain scale (BPS). Tool (IV): Daily sedative interruption outcomes assessment tool Results: the study results revealed that 67.7% of the studied patients were in the age group from 56-65 years old, with a mean of age was 60.87± 9.35. 57.4% of them were male .44.1% of the studied patients were sedated with fentanyl and 36.8% of the studied patients were on SIMV mode. There were a high statistically significant difference regarding Richmond agitation sedation scale of the studied patients through 5 days from admission (p-value=0.000*). Conclusion: a highly statistically significant difference regarding Richmond Agitation Sedation scale of the studied patients through 5 days from admission. A highly statistically significant relation among studied patients Richmond Agitation sedation scale, length of ICU stay, and duration of MV Recommendation: Sedation protocol should be standardized in every critical care unit and every health care person working in the ICU should be made aware of the protocol used