This study aimed to find out the relationship between human resource management and Knowledge Management Practices. To achieve the study goals, a descriptive research design has been used, and in this research, the researcher relied on the quantitative method. The researcher selected 67 universities in Malaysia for this study with a total population of 670 HR employees and a sample size of 245 participants. A questionnaire was developed and used as a tool for this study. The result shows that the variables (Human Resource Management) explain (82.3%) of the variance in (Knowledge Management Practices),