This review delves into the connection among illnesses, drugs, and dry mouth, focusing on the signs and treatment approaches. Dry mouth, characterized by decreased saliva production, emerges as an issue influenced by various health conditions and medications. Autoimmune diseases like Sjögren's syndrome, metabolic irregularities in diabetes, and ailments such as arthritis and high blood pressure contribute to the mouth showing up as ongoing dryness, swallowing difficulties, and increased susceptibility to gum problems. Medications ranging from blood pressure medications to drugs can worsen mouth, posing challenges to oral wellness. Managing this condition requires an approach. For illnesses, a dual strategy involves treating the root cause with therapies while also addressing oral symptoms with specific interventions. In cases of medication-induced mouth, evaluating medications thoroughly, exploring alternatives when possible, and providing relief for symptoms are crucial steps. Stimulating glands and educating on health practices and preventive measures are vital components of holistic dry mouth management. Collaborative efforts between dental experts are key for care that focuses on conducting medication reviews and tailoring interventions to individual needs. Integrating treatments based on patient preferences enhances the effectiveness of care overall. As we learn more, adjusting our methods will help enhance the results for patients, highlighting the significance of an individualized approach when dealing with mouth