The treatment of acid mine drainage using clays has been widely investigated and has produced the most promising results in unravelling the issue of heavy metals present in AMD that are responsible for endangering the environment and human beings. However, clays in its pure form fails to perform well in AMD with high concentrations of metals. The modification of the already available clays and the production of the cheap synthetic form may be an alternative solution to achieve clean water within the government legislated maximum concentrations for human consumption. Nano-clays were used as adsorbents to evaluate their ability to remove heavy metals from acid mine drainage with a specific focus on manganese and iron. The two nano-clay adsorbents used in this study are modified bentonite (MB) and hydrotalcite (HT) clays. Batch adsorption experiments were carried out to determine the adsorption capacity of both clays. The HT shows an adsorption capacity of 159mg/g and 5.44 mg/g for MB. The best fit was achieved with the pseudo-second order model. Desorption studies revealed that modified bentonite may be easier to regenerate than hydrotalcite with 97.5% desorption of Fe at a concentration of 0.1N of HCl. The results of this research work have shown the effectiveness of nano clays as alternative adsorbents for AMD remediation.