Purpose: Modern orthopaedic and maxillofacial procedures always call for a quick bone tissue regeneration to fill in surgically generated gaps or quickly boost bone implant fixation. Methodology: 2 months prior to lateral sinus floor elevation, 3 bimaxillary premolars (P2, P3, and P4) were retrieved from 4 individuals. Each sinus was assigned either the test group or the control group after the lateral elevation of the sinus membrane. Upon lateral sinus floor elevation, the choice of a collagenated synthetic bone graft with PDRN (test group) or a collagenated synthetic bone graft lacking PDRN (control group) was performed on the sinuses. Results: There were no appreciable differences in AH, PH, BICp, BICa total, BICa coronal, and BICa middle values amongst sinuses in the control and test groups (all P>0.05). In comparison to the sinuses in the control group (55.6%22.1%), the BICa apical of the test group's sinuses (76.7%9.3%) displayed statistically higher values (P=0.038). Statistics revealed that there were differences in pNB, pRBP, and pFVT between the two groups in AOI_A (P=0.038, P=0.028, and P=0.007, respectively). The samples from the control and test groups did not substantially differ in terms of pNB, pRBP, and pFVT in AOI_C and AOI_M (all P>0.05). Conclusions: According to the histologic results, lateral sinus floor elevation with PDRN may promote early new bone development and increase bone-to-implant interaction