End-of-life care is a pivotal component of healthcare, demanding specialized attention and empathy. Family physicians are at the forefront of providing support, comfort, and medical expertise to patients and their families during this delicate stage. This review seeks to consolidate the most effective strategies for family physicians in end-of-life care, encompassing communication, symptom management, advance care planning, and the facilitation of collaborative efforts with other healthcare professionals. Additionally, the review delves into the obstacles and challenges that family physicians may face in delivering end-of-life care, offering actionable recommendations to enhance the quality of care provided. The review's insights underscore the indispensable role of family physicians in ensuring the delivery of exceptional end-of-life care. It emphasizes the necessity for continuous education and support to empower family physicians in this critical realm of healthcare, ultimately aiming to enhance the standard of care for patients and their families during this poignant phase of life.