Background: The primary health care system relies heavily on the crucial roles played by health assistants in assisting healthcare professionals, monitoring service delivery, and promoting community health. However, there are challenges such as lack of clarity in job descriptions, inadequate training, workload issues, and barriers at the community level that hinder the effective functioning of health assistants in primary health centers. Addressing these challenges is essential to ensure the delivery of high-quality, patient-centered care. Objective: This research article aims to assess the responsibilities and duties of Health Assistants in Primary Health Centers, evaluate their impact on patient care and health outcomes, explore the training and qualifications required for Health Assistants, investigate the challenges and barriers they face, and identify opportunities for improvement in their roles. Conclusion: Health Assistants play a vital role in the healthcare system, but various challenges impede their effectiveness. Addressing these challenges through comprehensive training, adequate staffing, and cultural competency is crucial for improving patient care and health outcomes. The qualifications required for Health Assistants encompass a diverse skill set, highlighting the importance of possessing the necessary knowledge, skills, and attributes for success in this role. Ultimately, the dedication and hard work of Health Assistants are essential for promoting the health and well-being of individuals and communities served by Primary Health Centers.