Background: The prevalence of mental health problems has been on the rise globally, highlighting the importance of Mental Health First Aid provided by individuals in the social network of those affected. Nurses play a crucial role in promoting mental health and well-being through various interventions and strategies. Objective: This review aims to explore how nurses can promote mental health and well-being among their patients, examine specific interventions and strategies used by nurses, assess the impact of nurse-led mental health promotion initiatives on patient outcomes, identify barriers and challenges faced by nurses in promoting mental health, investigate the training and education needs of nurses in mental health promotion, and examine the attitudes and beliefs of nurses towards mental health and well-being promotion. Conclusion: Nurse-led mental health promotion initiatives have shown significant improvements in patient outcomes by emphasizing patient education, personalized care, evidence-based practices, and community outreach. Despite facing barriers such as stigma, resource limitations, time constraints, lack of training, and heavy workloads, nurses' attitudes and beliefs towards mental health promotion significantly impact the quality of care provided. By addressing these challenges and fostering positive attitudes and beliefs, nurses can continue to play a crucial role in improving mental health outcomes for individuals and communities.