The role of nurses in promoting vaccination uptake is crucial in ensuring public health and preventing the spread of infectious diseases. Nurses play a significant role in educating the public about the importance of vaccinations, addressing vaccine hesitancy, and administering vaccines. This review article examines the various ways in which nurses contribute to increasing vaccination uptake rates, including their role in vaccine education, advocacy, and community outreach. The article also explores the challenges that nurses face in promoting vaccination uptake and provides recommendations for enhancing their impact in this critical area of healthcare. By highlighting the essential role of nurses in vaccination promotion, this review aims to underscore the importance of leveraging nursing expertise to improve vaccination rates and protect public health.