Nursing care coordination plays a crucial role in optimizing laboratory test utilization for complex patient cases. In healthcare settings, particularly with complex patient cases, efficient utilization of laboratory tests is essential for accurate diagnosis and treatment planning. Nursing care coordination involves the systematic organization and management of healthcare services to ensure that patients receive timely and appropriate care. This review article explores the importance of nursing care coordination in guiding the appropriate use of laboratory tests for complex patient cases. By effectively coordinating care among healthcare providers, nurses can help streamline the ordering and interpretation of laboratory tests, leading to improved patient outcomes and cost-effective healthcare delivery. The article also discusses the challenges and barriers that nurses may encounter in coordinating care related to laboratory test utilization and provides recommendations for enhancing nursing care coordination practices in this context.