Chronic diseases pose significant challenges to patients, impacting their quality of life and requiring ongoing management. Pain management is a critical aspect of comprehensive care for patients with chronic diseases, as it affects various aspects of their physical, emotional, and social well-being. Nurses play a central role in pain assessment, intervention, and patient education, contributing to the overall management of chronic diseases. This paper explores the multifaceted role of nursing in pain management and the delivery of comprehensive care for patients with chronic diseases, highlighting evidence-based practices and strategies to optimize patient outcomes.