Abstract: Background: Chronic kidney disease (CKD) poses a significant burden on healthcare systems, particularly in Australia, with rural and remote areas disproportionately affected. Patients with CKD often require complex medication regimens, but medication nonadherence is a common issue leading to poor outcomes. Pharmacists are well-positioned to support medication adherence in CKD patients through education, monitoring, and collaboration with healthcare teams. Objective: This review aims to assess the role of pharmacists in improving medication adherence among CKD patients, explore barriers to adherence in this population, and examine the impact of pharmacist interventions on adherence. Conclusion: Pharmacist-led interventions are vital for enhancing medication adherence in CKD patients. These interventions address barriers such as literacy issues and limited health access, ultimately improving patient outcomes. Evidence-based strategies, including multimodal education and interprofessional collaboration, have shown positive results in enhancing adherence and patient satisfaction. Patient preferences support the need for tailored pharmacist interventions, highlighting the importance of personalized approaches in supporting medication adherence for CKD patients. Increased utilization of pharmacist services is essential to optimize medication adherence and enhance the quality of care for individuals with CKD.