Background: There has been an increasing acknowledgement of the need for interprofessional cooperation in healthcare in recent years. Aim of the Study: This review thoroughly analyzes the significance of pharmacist-nurse interactions in facilitating clinical workflow, specifically exploring the advantages, difficulties, and methods for improving collaborative practice. Materials and Methods: The literature reviewed in the analysis included a wide variety of research methods, offering valuable information on the potential benefits and challenges of cooperation between pharmacists and nurses. Results: The examination of the literature demonstrated that cooperative partnerships between pharmacists and nurses may enhance the management of medications and the delivery of patient care, resulting in improved patient outcomes. The research identified key themes that highlighted the advantages of multidisciplinary teamwork, such as greater drug safety, improved patient education, and more effective care delivery. Nevertheless, the analysis also identified many obstacles, such as language difficulties, unclear job responsibilities, and limitations within the organization, which might impede the successful cooperation between pharmacists and nurses. The results underscore the need for improved cooperation and correspondence among these medical practitioners in order to surmount the highlighted obstacles and optimize the advantages of their alliance. Potential methods to increase collaborative practice between pharmacists and nurses include interprofessional education, standardized communication procedures, and shared decision-making processes. Conclusion: This study enhances the overall comprehension of the present condition of pharmacist-nurse partnerships in clinical practice, emphasizing the possible advantages and difficulties linked to their cooperation. The integrated data offers valuable insights for healthcare professionals, educators, and legislators to create interventions and legislation that seek to enhance pharmacist-nurse partnerships and enhance clinical workflow.