Neuroprotective agents are capableto protect the peripheral nervous system (PNS) and central nervous system (CNS) against neuronal damage and neurodegenerative conditions. Herbal drugs having both medicinal value and long-term health-promoting. Herbal drugs from different medicinal plant species have various phytochemicals and bioactive compounds with neuroprotective abilities. A wide range of discoveries and studies have proved that medicinal herbs, plant extracts, and their metabolites have strong potential as theneuroprotective agent. Hence the herbal plants may be a valuable source of drugs against neurodegenerative diseases such as Parkinson's disease (PD), schizophrenia, Alzheimer's disease (AD), depression, dementia, seizure, cerebrovascular deficit, and head injury. The present review will highlight the neuroprotective role of herbal drugs and their metabolites against neurodegenerative diseases and other related conditions, targeting their therapeutic potential and mechanism of action.