Public health campaigns play a critical role in promoting disease prevention by raising awareness, changing behaviors, and influencing policy decisions. This review article examines the effectiveness of various public health campaigns in addressing different diseases and health issues. The impact of these campaigns on individual behavior, community health, and overall public well-being is analyzed through a comprehensive review of existing literature and case studies. The article begins by discussing the importance of public health campaigns as a tool for educating the public about disease prevention strategies, such as vaccination, hand hygiene, and healthy lifestyle choices. It explores how these campaigns can reach diverse populations and effectively communicate key health messages to promote behavior change. Case studies on successful campaigns, such as anti-smoking initiatives, HIV/AIDS awareness programs, and childhood vaccination drives, are presented to illustrate the positive outcomes of well-designed public health interventions. Furthermore, the review examines the role of social media and digital technologies in enhancing the reach and impact of public health campaigns. It discusses the use of targeted messaging, interactive platforms, and data analytics to tailor campaigns to specific demographics and monitor their effectiveness in real-time. The potential of partnerships between public health agencies, non-profit organizations, and private sector stakeholders in amplifying the reach and sustainability of disease prevention campaigns is also explored.