This study was conducted to identify the role of the alcoholic extract of Spirulina algae nanoloaded with nano-zinc oxide in improving the negative effects of hydrogen peroxide-induced oxidative stress on the female reproductive system in rats. (35) female rats, whose weights ranged between (180-200) g, and their ages ranged between )8-9) weeks, were used in the experiment. The animals were randomly divided into seven groups, each group included five rats. The groups were divided in the experiment as follows: the control group was dosed with normal saline, the first treatment (T1) was treated with hydrogen peroxide in drinking water, and the second treatment (T2) was treated with alcoholic extract of Spirulina platensis at a concentration (300 mg/kg), the third treatment (T3) was treated with nano extract of Spirulina platensis at a concentration (250 mg/kg), the fourth treatment (T4) was treated with nano zinc oxide at a concentration (20 mg/l), the fifth treatment (T5) was treated with hydrogen peroxide and dosed with normal extract of Spirulina platensis, the sixth treatment (T6) was treated with hydrogen peroxide and dosed with nano extract of Spirulina platensis. After the end of the experiment, which lasted 21 days, the animals were anesthetized and their weights recorded, and blood was drawn from the heart directly for biochemical tests. The following organs (uterus and ovaries) were removed and their weights were recorded.