Background: Ultrasound diagnostic imaging (USI) is increasingly used in sports medicine, orthopedics, and rehabilitation due to its advantages such as being radiation-free, cost-effective, portable, and non-invasive. Musculoskeletal USI provides valuable information for assessing musculoskeletal structures and function, aiding in prompt diagnosis and treatment planning. Physical therapists (PTs) play a crucial role in musculoskeletal care, with a practice framework emphasizing anatomy, pathoanatomy, and biomechanics. However, there is a reported gap in PTs' knowledge and skills regarding the utilization of USI compared to other imaging modalities like radiography and MRI. Objective: This study aims to explore the current utilization of ultrasound in musculoskeletal imaging within physiotherapy, evaluate its effectiveness in diagnosing and monitoring musculoskeletal conditions, and assess its role in therapeutic interventions in physiotherapy practice. Conclusion: Musculoskeletal ultrasound has shown promise in diagnosing various conditions such as meniscal injuries, ligament tears, tendon pathologies, and nerve injuries. Dynamic ultrasound protocols enable real-time visualization of structures during movement, aiding in accurate assessments. Additionally, interventional ultrasound can guide treatment interventions, such as needle placements for injections or hydrodissection procedures. Moreover, therapeutic ultrasound, particularly Low-intensity pulsed ultrasound (LIPUS), has emerged as a non-invasive modality for promoting tissue regeneration and managing soft tissue injuries. Studies have highlighted the effectiveness of LIPUS in accelerating fracture healing, reducing inflammation, and modulating neural activity in various soft tissues. Overall, integrating ultrasound into physiotherapy practice can enhance diagnostic accuracy, treatment precision, and patient outcomes in musculoskeletal care.