Background: Vitamin D is an essential nutrient for bone growth, mineralization, and other metabolic processes in the human body. Hence, insufficiency or deficiency of this vitamin can have long-term effects, particularly for children. Objectives: The aim of this study was to assess the role of vitamin d supplement in children with rickets in Saudi Arabia. Methodology: Following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, this systematic review was carried out. Results: children who received supplementation had a mean increase in serum vitamin D levels from 10.5 ng/ml to 28.3 ng/ml, while the non-supplemented group had a mean decrease from 9.8 ng/ml to 7.2 ng/ml. moreover, 80% of the children with rickets had vitamin D deficiency, with a mean serum vitamin D level of 8.7 ng/ml. After 6 months of vitamin D supplementation, the children showed a significant improvement in their vitamin D levels, with a mean increase to 27.4 ng/ml. Additionally, the children also showed an improvement in their bone mineral density. Conclusion: this study highlighted the significant impact of vitamin D supplementation in treating rickets in children, particularly in regions like Saudi Arabia where there is a high prevalence of vitamin D deficiency despite abundant sunlight. The results show that children who received vitamin D supplementation experienced a substantial improvement in their vitamin D levels and clinical symptoms compared to those who did not receive supplementation. Additionally, the study demonstrates that vitamin D supplementation plays a crucial role in increasing bone mineral density, thereby addressing the skeletal abnormalities associated with rickets.