One of the most prevalent psychiatric conditions impacting people globally is insomnia. Patients with insomnia struggle to fall asleep, stay asleep, or wake up early in the morning with or without a drowsy mood. It often interferes with daily activities. Numerous studies conducted worldwide indicate that 10% to 30% of people suffer from insomnia. Sleep disorder can either occur for few days or for longer period, known as primary and secondary insomnia. Anxiety, stress and depression are the commonest causes of insomnia. In Homoeopathy Miasm means an obstacle to cure. Dr Samuel Hahnemann (Father of Homoeopathy) used the term "miasm" to describe the causes to disease and to remove the cause Homoeopathy has Antimiasmatic treatment. This study supports the importance of Homoeopathic Antimiasmatic treatment for insomnia. Here we intended to investigate whether Homoeopathic remedies are effective in treating patients of insomnia. OBJECTIVE: The objective of this study was to investigate the significance of antimiasmatic homoeopathic medicines for the treatment of insomnia. METHODS: It is a single-blind, non-randomized clinical trial, conducted at the OPD of Bharati Vidyapeeth (deemed to be university) Homeopathic college and research Centre, Pune. The study includes 33 clinically diagnosed cases of insomnia of which 30 cases were administered the homoeopathic medicine selected on the basis of miasmatic background and totality of symptoms. The improvement of symptoms based on severity and intensity of insomnia was checked according to the Insomnia severity scale.