The interplay between pharmaceutical care and nursing in the preparation of medications is a critical yet often underexplored facet of healthcare delivery. This article critically examines the complementary roles of pharmacists and nurses, highlighting the synergy that exists between the two professions in ensuring the safety and efficacy of medication administration. Through a comprehensive review, we explore the distinct yet interconnected responsibilities of each discipline, the challenges impeding their collaboration, and the significant impact this collaboration has on patient care outcomes. Strategies to enhance interprofessional collaboration, including communication improvements, integrated care models, and policy developments, are discussed. The article underscores the necessity of fostering a collaborative environment to optimize healthcare delivery, improve patient safety, and increase the efficiency of medication management processes. Future directions for research and practice are proposed, emphasizing the need for innovative approaches to education and technology that support the evolving roles of pharmacists and nurses in a dynamic healthcare landscape.