The use of antibiotics in dental practice is a common and often necessary intervention to manage various oral infections and prevent systemic complications. However, the overuse and misuse of antibiotics in dentistry have raised concerns regarding the development of antibiotic resistance, posing a significant public health threat. This review article aims to provide a comprehensive overview of the current practices, challenges, and implications of antibiotic use in dental care, with a specific focus on antibiotic resistance. The article discusses the mechanisms of antibiotic resistance in oral bacteria, factors contributing to the emergence of resistance, and strategies to mitigate the development of resistance in dental settings. Furthermore, the review explores the impact of antibiotic stewardship programs, guidelines for prudent antibiotic prescribing, and alternative approaches to managing dental infections without relying solely on antibiotics. By critically examining the role of antibiotics in dental practice and their potential consequences on antibiotic resistance, this article highlights the importance of judicious antibiotic use and the need for ongoing education and awareness among dental professionals and patients.