Siddha system of medicine is one of the indigenous system of medicine practised in India. The Siddhars who are the exponents of this system classified the diseases on the basis of three humours Vatha, Pitha, Kaba and signs and symptoms. All the Siddha drugs are natural products obtained from herbs, metals, minerals and animal kingdom which are given by the Siddhar’s spiritual knowledge to this society. Siddha sastric preparation Athimathura chooranam is a poly herbo mineral formulation and it is the safe and efficacious medicine used traditionally for the treatment of Respiratory illness. This review describes the chemical constituents, pharmacological and therapeutic uses of its ingredients thereby substantiating the traditional claims of Athimathura chooranam under scientific evidence.