Background: Oxidative stress has been considered as contributory aspect for major complications of diabetes mellitus consisting of diabetes. The aim of this study was to examine the therapeutic effect of Myricetin in streptozotocin (STZ) induced diabetes through measuring biochemical parameters, oxidative indicators and histopathological examination of renal tissues. Results: Administration of dose of STZ (55 mg/kg of body weight) intraperitoneal ended in diabetes in rats as indicated by increase in serum glucose level. Besides, STZ treatment led to depletion of antioxidant enzymes together with superoxide dismutase (SOD), glutathione (GSH) and catalase (CAT). Administration of Myricetin at the dose of 1, 2 and 5 mg/kg extensively decreased biochemical parameters. Myricetin was observed to improved antioxidant enzymes ranges and offered safety in opposition to lipid peroxidation (LPO).STZ administered rats shows elevated level of TNF-α and IL-6 and Myricetin treated rats inhibited the elevated level of cytokine. Conclusion: This study concluded that Myricetin may additionally modulate oxidative stress and protected renal tissues from STZ injury. Improvement in renal histopathological architecture further confirmed in vivo antioxidant activity of Myricetin in STZ induced diabetes.